Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects Publication Pharmacokinetics, Safety, and Tolerability of Teduglutide, a Glucagon-like Peptide-2 (GLP-2) Analog, Following Multiple Ascending Subcutaneous Administrations in Healthy Subjects Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is currently being evaluated for the treatment of short-bowel…Certara2008年11月1日
Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential Publication Maraviroc: In Vitro Assessment of Drug-drug Interaction Potential AIMS: To characterize the cytochrome P450 enzyme(s) responsible for the N-dealkylation of maraviroc in vitro,…Certara2008年10月1日
Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery Publication Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending Aorta in Patients Undergoing Cardiac Surgery Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta…Certara2008年10月1日
Accurate and Interpretable Computational Modeling of Chemical Mutagenicity Publication Accurate and Interpretable Computational Modeling of Chemical Mutagenicity We describe a method for modeling chemical mutagenicity in terms of simple rules based on…Certara2008年9月5日
Integrating Systems Approaches into Pharmaceutical Sciences Publication Integrating Systems Approaches into Pharmaceutical Sciences During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…Certara2008年9月2日
Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability Publication Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…Certara2008年8月1日
A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally Publication A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally BACKGROUND: The spleen tyrosine kinase (Syk) is recognized as a potential pharmaceutical target for the…Certara2008年7月1日
Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease Publication Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…Certara2008年7月1日
Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain Publication Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain The aim of this study was to develop a pain relief model for a cyclooxygenase…Certara2008年7月1日
A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor Publication A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor CggR belongs to the SorC family of bacterial transcriptional regulators which control the expression of…Certara2008年6月1日