CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene
Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…
Certara2008年4月30日
The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition
BACKGROUND: Erlotinib is an orally active antitumor agent. Analyses in vitro using human liver microsomes and…
Certara2008年1月1日
Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation
In adapting to the challenge to make more informed selection of compounds for development, the…
Certara2007年12月1日
In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators
Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly…
Certara2007年11月1日
Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions
Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…
Certara2007年10月1日
Prediction of Intestinal First-pass Drug Metabolism
Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…
Certara2007年10月1日
Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
An analysis of reported hepatic abundances of CYP3A4 and 3A5 indicated that values determined by…
Certara2007年10月1日
A Systematic Comparison of Software Dedicated to Meta-analysis of Causal Studies
Our objective was to systematically assess the differences in features, results, and usability of currently…
Certara2007年9月10日
Modeling, Simulation, and the Critical Path
The benefits of modeling and simulation fall into two categories: Increased certainty in trial designs…
Certara2007年9月6日
Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems
Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…
Certara2007年9月1日
