pre-update Archives

Publication

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…

Certara2008年6月1日

Publication

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Unbound IC50 (IC50,u) values of 15 drugs were determined in eight recombinantly expressed human cytochromes P450…

Certara2008年6月1日

Publication

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs…

Certara2008年5月1日

Publication

Development of CYP2D6 and CYP3A4 in the First Year of Life

Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…

Certara2008年5月1日

Publication

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…

Certara2008年4月30日

Publication

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

BACKGROUND: Erlotinib is an orally active antitumor agent. Analyses in vitro using human liver microsomes and…

Certara2008年1月1日

Publication

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In adapting to the challenge to make more informed selection of compounds for development, the…

Certara2007年12月1日

Publication

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly…

Certara2007年11月1日

Publication

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…

Certara2007年10月1日

Publication

Prediction of Intestinal First-pass Drug Metabolism

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…

Certara2007年10月1日

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pre-update

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Development of CYP2D6 and CYP3A4 in the First Year of Life

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Prediction of Intestinal First-pass Drug Metabolism

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