Model-based Development of Gemcabene, a New Lipid-altering Agent Publication Model-based Development of Gemcabene, a New Lipid-altering Agent The purpose of this study was to evaluate the value of model-based, quantitative decision making…Certara2005年10月7日
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Publication Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…Certara2005年9月1日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation Publication Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…Certara2005年9月1日
Modelling Approaches to Dose Estimation in Children Publication Modelling Approaches to Dose Estimation in Children Most of the drugs on the market are originally developed for adults and dosage selection…Certara2005年6月1日
Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity Publication Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…Certara2005年4月1日
Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials Publication Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…Certara2005年1月1日
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients Publication Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…Certara2005年1月1日
Pharmacokinetics of Dibutylphthalate in Pregnant Rats Publication Pharmacokinetics of Dibutylphthalate in Pregnant Rats Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late…Certara2004年12月1日
In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions Publication In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions Recently, metabolic drug-drug interactions (M-DDI) have raised some high-profile problems in drug development resulting in restricted use, withdrawal…Certara2004年12月1日
Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH Publication Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH Drug/metabolite ratios (MRs) are used as in vivo markers of enzyme activity. The ratios are…Certara2004年12月1日