Predicting the Clearance of CYP2C9 Substrates
Recently, Andersson et al. (2004) reported that quantitative predictions of hepatic clearance from in vitro…
Certara2004年12月1日
Cytochrome P450 3A Expression and Activity in the Human Small Intestine
Recently, von Richter et al measured the content of cytochrome P450 (CYP) 3A in paired…
Certara2004年10月1日
Pharmacogenetics—Expectations and Reality
Thirty years have passed since Mike Rawlins, the current chairman of the National Institute for…
Certara2004年7月1日
Prediction of Clearance from Recombinantly Expressed CYPs: Intersystem Extrapolation Factor (ISEF)
Recombinantly expressed human cytochromes P450 (rhCYPs) have been underused for the prediction of human drug…
Certara2004年2月1日
The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain
Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…
Certara2003年11月1日
The Effects of Dose Staggering on Metabolic Drug-drug Interactions
The purpose of this study was to investigate the effect of dose staggering on metabolic…
Certara2003年10月1日
Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis
Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…
Certara2003年1月1日
Combining Drug-disease and Economic Modeling to Inform Drug Development Decisions
Drug-disease models and clinical trial simulations are increasingly being used to support trial design and…
Certara2001年11月1日
A Population Pharmacokinetic/Pharmacodynamic Analysis of Repeated Measures Time-to-event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron
This paper presents and illustrates methodology for specifying, estimating, and evaluating a predictive model for…
Certara1999年12月1日
In Vivo Indices of Enzyme Activity—The Effect of Renal Impairment on the Assessment of CYP2D6 Activity
Urinary drug metabolite ratios and urinary recoveries of metabolites, have been used to assess specific…
Certara1999年6月1日
