Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions Publication Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions To develop physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and drug-drug interactions (DDI)…Certara2012年10月1日
Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings Publication Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings The physiological changes that occur in the maternal body and the placental-foetal unit during pregnancy…Certara2012年7月1日
From Pre-clinical to Human—Prediction of Oral Absorption and Drug-drug Interaction Potential Using Physiologically-based Pharmacokinetic (PBPK) Modeling Approach in an Industrial Setting: A Workflow by Using Case Example Publication From Pre-clinical to Human—Prediction of Oral Absorption and Drug-drug Interaction Potential Using Physiologically-based Pharmacokinetic (PBPK) Modeling Approach in an Industrial Setting: A Workflow by Using Case Example A case example is presented in which the physiologically based modeling approach has been used…Certara2012年3月1日
Physiologically-based PharmacoKinetic (PBPK) Modeling Tools: How to Fit with Our Needs? 論文 Physiologically-based PharmacoKinetic (PBPK) Modeling Tools: How to Fit with Our Needs? In 2005, a survey compared a number of commercial PBPK software available at the time,…Certara2012年3月1日
Using Simcyp to Project Human Oral Pharmacokinetic Variability in Early Drug Research to Mitigate Mechanism-based Adverse Events Publication Using Simcyp to Project Human Oral Pharmacokinetic Variability in Early Drug Research to Mitigate Mechanism-based Adverse Events Positive allosteric modulators ('potentiators') of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) have been shown to display…Certara2012年3月1日
Physiologically-based Pharmacokinetic Model for Topotecan in Mice Publication Physiologically-based Pharmacokinetic Model for Topotecan in Mice Topotecan is a chemotherapeutic agent of choice for the second-line treatment of recurrent ovarian cancer.…Certara2011年2月1日
Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science Publication Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of age in drug development and…Certara2011年2月1日
PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals Publication PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and…Certara2010年12月30日
Physiologically-based Mechanistic Modeling to Predict Complex Drug–drug Interactions Involving Simultaneous Competitive and Time-dependent Enzyme Inhibition by Parent Compound and Its Metabolite in Both Liver and Gut—The Effect of Diltiazem on the Time-course of Exposure to Triazolam Publication Physiologically-based Mechanistic Modeling to Predict Complex Drug–drug Interactions Involving Simultaneous Competitive and Time-dependent Enzyme Inhibition by Parent Compound and Its Metabolite in Both Liver and Gut—The Effect of Diltiazem on the Time-course of Exposure to Triazolam The aim of this study was to predict the magnitude of metabolic drug-drug interaction (mDDI)…Certara2010年3月18日
Physiologically-based Pharmacokinetics (PBPK) Publication Physiologically-based Pharmacokinetics (PBPK) Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many…Certara2009年6月1日