Karen Rowland Yeo氏、Eva Gil Berglund氏、Yuan Chen氏による論文「PBPKモデリングに基づく用量最適化：最新動向と今後の展望」（Clinical Pharmacology & Therapeutics掲載）は、State-of-the Art and Future” by Karen Rowland Yeo, Eva Gil Berglund, and Yuan Chen, published in Clinical Pharmacology & Therapeutics, reviews the current landscape of physiologically-based pharmacokinetic (PBPK) modeling in drug development. It highlights PBPK’s expanding role in dose optimization, regulatory submissions, and its application to diverse and underrepresented populations. The article also discusses challenges, such as model validation and future directions, including the integration of PBPK with machine learning and Quantitative Systems Pharmacology (QSP) to enhance personalized medicine.

Reference: Clinical Pharmacology & Therapeutics, State of the Art Review, Open Access.