Using Quantitative Systems Pharmacology Modelling to Accelerate Drug Development

Model informed drug development (in silico modelling) continues to be a game changer in accelerating drug development. Quantitative Systems Pharmacology (QSP) is one such technology, which employs virtual patients in virtual clinical trials, allowing more approaches to be investigated than would be possible in the real world. Examples described here demonstrate the impact on some of today’s most urgent medical needs, including evaluating a potential treatment for Alzheimer’s disease, paediatric dosing for a COVID-19 vaccine, and evaluation of novel therapies for irritable bowel disease.