What is “Adjusted” r-squared?
Linear regression is a common tool that the pharmacokineticist uses to calculate elimination rate constants.…
Nathan Teuscher2013年10月7日
Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body
When I first began learning about pharmacokinetics, I was often confused by the mean residence…
Certara2013年3月28日
What is a Loading Dose?
Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…
Certara2013年3月22日
The Superposition Principle
Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…
Nathan Teuscher2013年3月14日
Saturable Drug Absorption
Drug absorption is the process by which a drug molecule moves from the site of…
Nathan Teuscher2013年2月26日
Nonlinear PK: What Does That Mean?
You may come across a phrase like the following and wonder what it means: “……
Certara2013年2月17日
Why Cmax is a Continuous Variable and Tmax is a Categorical Variable
The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…
Nathan Teuscher2013年2月11日
What is Quantification Anyway?
Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…
Nathan Teuscher2013年2月5日
Calculating Urine PK Parameters
Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…
Certara2012年12月6日
What Can We Learn from a Human Mass Balance Study?
Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…
Nathan Teuscher2012年11月27日
