Publication Archives

Publication

Trends in Oral Drug Bioavailability Following Bariatric Surgery: Examining the Variable Extent of Impact on Exposure of Different Drug Classes

Changes to oral drug bioavailability have been observed post bariatric surgery. However, the magnitude and…

webdev2012年11月1日

Publication

A Pregnancy Physiologically-based Pharmacokinetic (p-PBPK) Model for Disposition of Drugs Metabolized by CYP1A2, CYP3A4, and CYP2D6

Pregnant women are usually not part of the traditional drug development program. Pregnancy is associated…

webdev2012年10月9日

Publication

Ontogeny of Oral Drug Absorption Processes in Children

A large proportion of prescribed drugs to children are administered orally. Age-related change in factors…

webdev2012年10月8日

Publication

Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions

To develop physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and drug-drug interactions (DDI)…

webdev2012年10月1日

Publication

Methods of Solving Rapid Binding Target-mediated Drug Disposition Model for Two Drugs Competing for the Same Receptor

The target-mediated drug disposition (TMDD) model has been adopted to describe pharmacokinetics for two drugs competing for the same receptor. A rapid binding assumption introduces total receptor and total drug concentrations while free drug concentrations C…

webdev2012年10月1日

Publication

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

A significant barrier to realization of the full potential of clozapine as a therapeutic agent…

webdev2012年10月1日

Publication

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested…

webdev2012年10月1日

Publication

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Impact of prenatal PCB exposure on birth weight was investigated in various children cohorts and…

webdev2012年10月1日

Publication

Pharmacokinetic and Pharmacodynamic Analysis of Efavirenz Dose Reduction Using an In Vitro-In Vivo Extrapolation Model

The pharmacokinetics (PK) of efavirenz (EFV) is characterized by marked inter-patient variability that correlates with…

webdev2012年10月1日

Publication

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

To date, there has been little investigation of the risk for drug-drug interactions involving monoclonal…

webdev2012年9月1日

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論文

Trends in Oral Drug Bioavailability Following Bariatric Surgery: Examining the Variable Extent of Impact on Exposure of Different Drug Classes

A Pregnancy Physiologically-based Pharmacokinetic (p-PBPK) Model for Disposition of Drugs Metabolized by CYP1A2, CYP3A4, and CYP2D6

Ontogeny of Oral Drug Absorption Processes in Children

Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions

Methods of Solving Rapid Binding Target-mediated Drug Disposition Model for Two Drugs Competing for the Same Receptor

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Pharmacokinetic and Pharmacodynamic Analysis of Efavirenz Dose Reduction Using an In Vitro-In Vivo Extrapolation Model

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

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