Publication Archives

Publication

pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization

Dr. Mark Sale, Dr. Keith Nieforth, James Craig and peers from industry, healthcare, and academia…

Danielle Pillsbury2024年6月28日

Publication

Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain

Danielle Pillsbury2024年6月26日

Publication

PBPK モデリングに基づく用量最適化：最新動向と今後の展望

The article "Dose Optimization Informed by PBPK Modeling: State-of-the Art and Future" by Karen Rowland…

Jim Gallagher2024年5月6日

Publication

Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model

The rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK) models, particularly for…

Jim Gallagher2024年5月6日

Publication

Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

Physiologically-based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption,…

Jim Gallagher2024年4月26日

Publication

The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Jim Gallagher2024年3月4日

Publication

Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator

The Simcyp Simulator is a software platform for population physiologically-based pharmacokinetic (PBPK) modeling and simulation.…

Jim Gallagher2024年2月23日

Publication

The interaction of core modules as a basis for elucidating network behavior determining Parkinson’s disease pathogenesis

It is well-established that misfolded alpha-synuclein (alpha-syn) is a histopathological marker of Parkinson's disease. Given…

Jim Gallagher2024年2月14日

Publication

Treatment patterns of patients with HR+/HER2- metastatic breast cancer receiving CDK4/6 inhibitor-based regimens: a cohort study in the French nationwide healthcare database

To assess real-world treatment patterns in patients diagnosed with hormone receptor positive (HR+), human epidermal…

Jim Gallagher2024年1月17日

Publication

Real-world application of PBPK in drug discovery

The utility of PBPK models in support of drug development has been well documented. During…

Jim Gallagher2024年1月11日

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論文

pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization

Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain

PBPK モデリングに基づく用量最適化：最新動向と今後の展望

Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model

Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator

The interaction of core modules as a basis for elucidating network behavior determining Parkinson’s disease pathogenesis

Treatment patterns of patients with HR+/HER2- metastatic breast cancer receiving CDK4/6 inhibitor-based regimens: a cohort study in the French nationwide healthcare database

Real-world application of PBPK in drug discovery

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