Central Nervous System (CNS) Archives

On-Demand Webinar

Using Virtual Twin Technology to Predict Drug Exposure in Individual Patients

In this webinar, Dr. Tom Polasek, a clinical pharmacologist at Certara Strategic Consulting, explained how…

Danielle Pillsbury2018年3月8日

Publication

Prediction of Olanzapine Exposure in Individual Patients Using Physiologically-based Pharmacokinetic Modeling and Simulation

Danielle Pillsbury2017年11月30日

Poster

Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model

Danielle Pillsbury2017年6月6日

Publication

Effect of Disease-related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats

Danielle Pillsbury2017年5月1日

Publication

Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy

Danielle Pillsbury2016年12月5日

Publication

The Pharmacokinetics of Transdermal Flunixin Meglumine in Holstein Calves

This study describes the pharmacokinetics of topical and intravenous (IV) flunixin meglumine in Holstein calves.…

Danielle Pillsbury2016年12月1日

Publication

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Danielle Pillsbury2016年11月17日

Blog

Modeling and Simulation Guides Dosing for a New Anti-psychotic Drug

Drug development is becoming more complex than ever. Regulatory agencies expect sponsors to consider a…

Certara2016年10月21日

Publication

Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves

OBJECTIVE To describe plasma pharmacokinetic parameters and tissue elimination of flunixin in veal calves. ANIMALS…

Danielle Pillsbury2016年6月1日

Publication

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…

Danielle Pillsbury2016年6月1日

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中枢神経系(CNS)

Using Virtual Twin Technology to Predict Drug Exposure in Individual Patients

Prediction of Olanzapine Exposure in Individual Patients Using Physiologically-based Pharmacokinetic Modeling and Simulation

Predicting Diclofenac Systemic and Synovial Fluid Concentrations After Dermal Application Using the Multi-phase Multi-layer MechDermA PBPK Model

Effect of Disease-related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats

Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy

The Pharmacokinetics of Transdermal Flunixin Meglumine in Holstein Calves

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Modeling and Simulation Guides Dosing for a New Anti-psychotic Drug

Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

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