Understanding LC/MS/MS
The most common bioanalytical method in use today is LC/MS/MS, or liquid chromatography (LC) tandem…
Certara2014年7月15日
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
Certara2014年7月14日
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin
Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…
Certara2014年7月9日
What is HPLC/UV?
In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…
Certara2014年7月8日
Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients
Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…
Certara2014年6月1日
The ISoP Standards and Best Practices Committee
The mission of the International Society of Pharmacometrics (ISoP) Standards and Best Practices Committee is…
Certara2014年6月1日
Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients
Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…
Certara2014年5月21日
What Can We Learn from Dose Normalization?
Dose normalization is a common calculation performed with pharmacokinetic parameters. The general process is to…
Certara2014年5月19日
Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials
Model-based drug development in oncology is still lagging despite a good momentum in the clinical…
Certara2014年4月1日
