Modeling and Simulation - PK/PD Archives | Page 22 of 37

Publication

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…

Certara2014年6月1日

Publication

The ISoP Standards and Best Practices Committee

The mission of the International Society of Pharmacometrics (ISoP) Standards and Best Practices Committee is…

Certara2014年6月1日

Publication

The Posology of Oseltamivir in Infants with Influenza Infection Using a Population Pharmacokinetic Approach

Certara2014年5月27日

Publication

Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients

Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…

Certara2014年5月21日

Blog Knowledge Base

What Can We Learn from Dose Normalization?

Dose normalization is a common calculation performed with pharmacokinetic parameters. The general process is to…

Certara2014年5月19日

Publication

Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials

Model-based drug development in oncology is still lagging despite a good momentum in the clinical…

Certara2014年4月1日

Publication

Exploratory Modeling and Simulation to Support Development of Motesanib in Asian Patients with Non-small Cell Lung Cancer Based on MONET1 Study Results

The motesanib phase III MONET1 study failed to show improvement in overall survival (OS) in…

Certara2014年4月1日

Publication

Physiologically-based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction…

Certara2014年3月26日

Publication

Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults

Azithromycin's extensive distribution to proinflammatory cells, including peripheral blood mononuclear cells (PBMCs) and polymorphonuclear cells…

Certara2014年3月5日

Publication

Impact of Electrocardiographic Data Quality on Moxifloxacin Response in Thorough QT/QTc Studies

Thorough QT studies are typically conducted for drugs with systemic bioavailability and include a positive…

Certara2014年3月1日

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Modeling and Simulation – PK/PD

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

The ISoP Standards and Best Practices Committee

The Posology of Oseltamivir in Infants with Influenza Infection Using a Population Pharmacokinetic Approach

Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients

What Can We Learn from Dose Normalization?

Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials

Exploratory Modeling and Simulation to Support Development of Motesanib in Asian Patients with Non-small Cell Lung Cancer Based on MONET1 Study Results

Physiologically-based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

Population Pharmacokinetics of Azithromycin in Whole Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells in Healthy Adults

Impact of Electrocardiographic Data Quality on Moxifloxacin Response in Thorough QT/QTc Studies

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