What Can We Learn from a Human Mass Balance Study?
Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…
Certara2012年11月27日
Bioavailability
Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…
Certara2012年11月4日
Simulations Using a Drug-disease Modeling Framework and Phase 2 Data Predict Phase 3 Survival Outcome in First-line Non-small Cell Lung Cancer
Simulations were performed for carboplatin/paclitaxel (C/P) plus motesanib or bevacizumab vs. C/P as first-line treatment…
Certara2012年11月1日
Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery
Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…
Certara2012年11月1日
Designing a Clinical Drug-drug Interaction Study
After a much longer delay that I expected, I am back to blogging on a…
Certara2012年10月29日
Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain
A significant barrier to realization of the full potential of clozapine as a therapeutic agent…
Certara2012年10月1日
In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide
Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested…
Certara2012年10月1日
Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data
Impact of prenatal PCB exposure on birth weight was investigated in various children cohorts and…
Certara2012年10月1日
Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation
Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung…
Certara2012年9月1日
Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships
Armodafinil, the longer lasting R-isomer of racemic modafinil, improves wakefulness in patients with excessive sleepiness…
Certara2012年9月1日
