Modeling and Simulation - PK/PD Archives | Page 29 of 37

Publication

Simulations Using a Drug-disease Modeling Framework and Phase 2 Data Predict Phase 3 Survival Outcome in First-line Non-small Cell Lung Cancer

Simulations were performed for carboplatin/paclitaxel (C/P) plus motesanib or bevacizumab vs. C/P as first-line treatment…

Certara2012年11月1日

Publication

Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery

Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…

Certara2012年11月1日

Knowledge Base

Designing a Clinical Drug-drug Interaction Study

After a much longer delay that I expected, I am back to blogging on a…

Certara2012年10月29日

Publication

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

A significant barrier to realization of the full potential of clozapine as a therapeutic agent…

Certara2012年10月1日

Publication

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Metabolites in safety testing have gained a lot of attention recently. Regulatory agencies have suggested…

Certara2012年10月1日

Publication

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Impact of prenatal PCB exposure on birth weight was investigated in various children cohorts and…

Certara2012年10月1日

Publication

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung…

Certara2012年9月1日

Publication

Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships

Armodafinil, the longer lasting R-isomer of racemic modafinil, improves wakefulness in patients with excessive sleepiness…

Certara2012年9月1日

Publication

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Lesion count observed on brain magnetic resonance imaging scan is a common end point in…

Certara2012年9月1日

Publication

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma…

Certara2012年8月1日

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Modeling and Simulation – PK/PD

Simulations Using a Drug-disease Modeling Framework and Phase 2 Data Predict Phase 3 Survival Outcome in First-line Non-small Cell Lung Cancer

Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery

Designing a Clinical Drug-drug Interaction Study

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

In Vivo-formed Versus Preformed Metabolite Kinetics of Trans-resveratrol-3-sulfate and Trans-resveratrol-3-glucuronide

Relationship Between Prenatal Exposure to Polychlorinated Biphenyls and Birth Weight: A Systematic Analysis of Published Epidemiological Studies Through a Standardization of Biomonitoring Data

Phenanthrene Metabolism in Smokers: Use of a Two-step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder: A Pharmacokinetic and Pharmacodynamic Model for Predicting and Comparing Their Concentration-effect Relationships

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

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