What are Drug-drug Interactions Anyway?
A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…
Nathan Teuscher2011年1月5日
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…
Danielle Pillsbury2011年1月1日
Absorption Rate
The rate at which a drug enters the body after administration is called the absorption…
Nathan Teuscher2010年12月30日
What is a Half-life?
One of the most incorrectly used but most often quoted parameters is half life. The…
Nathan Teuscher2010年12月20日
Modeling Disease Progression in Acute Stroke Using Clinical Assessment Scales
This article demonstrates techniques for describing and predicting disease progression in acute stroke by modeling…
Danielle Pillsbury2010年12月1日
Development of a Modeling Framework to Simulate Efficacy Endpoints for Motesanib in Thyroid Cancer Patients
To develop a modeling framework that simulates clinical endpoints (objective response rate and progression-free survival)…
Danielle Pillsbury2010年11月1日
Population Pharmacokinetic/Pharmacodynamic Modeling for the Time Course of Tumor Shrinkage by Motesanib in Thyroid Cancer Patients
To develop a population pharmacokinetic/pharmacodynamic model describing the relationship between motesanib exposure and tumor response…
Danielle Pillsbury2010年11月1日
A Pharmacokinetic/Pharmacodynamic Model for Cardiovascular Safety Assessment of R1551
Pharmacokinetic-pharmacodynamic relationships are crucial in understanding a drug's arrhythmogenic potential. Models assist to quantitatively relate…
Danielle Pillsbury2010年8月21日
Relationship Between Exposure to Sunitinib and Efficacy and Tolerability Endpoints in Patients with Cancer: Results of a Pharmacokinetic/Pharmacodynamic Meta-analysis
In this pharmacokinetic/pharmacodynamic meta-analysis, we investigated relationships between clinical endpoints and sunitinib exposure in patients…
Danielle Pillsbury2010年7月1日
