Generics and Bioequivalence
As the debate about health care in the United States continues forward, the term “generic…
Certara2011年1月10日
What are Compartmental Models?
Learn about compartmental models and their importance in pharmacokinetics. Find out how they simplify drug…
Certara2011年1月5日
What are Drug-drug Interactions Anyway?
A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…
Certara2011年1月5日
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…
Certara2011年1月1日
Absorption Rate
The rate at which a drug enters the body after administration is called the absorption…
Certara2010年12月30日
What is a Half-life?
One of the most incorrectly used but most often quoted parameters is half life. The…
Certara2010年12月20日
Modeling Disease Progression in Acute Stroke Using Clinical Assessment Scales
This article demonstrates techniques for describing and predicting disease progression in acute stroke by modeling…
Certara2010年12月1日
Development of a Modeling Framework to Simulate Efficacy Endpoints for Motesanib in Thyroid Cancer Patients
To develop a modeling framework that simulates clinical endpoints (objective response rate and progression-free survival)…
Certara2010年11月1日
Population Pharmacokinetic/Pharmacodynamic Modeling for the Time Course of Tumor Shrinkage by Motesanib in Thyroid Cancer Patients
To develop a population pharmacokinetic/pharmacodynamic model describing the relationship between motesanib exposure and tumor response…
Certara2010年11月1日
A Pharmacokinetic/Pharmacodynamic Model for Cardiovascular Safety Assessment of R1551
Pharmacokinetic-pharmacodynamic relationships are crucial in understanding a drug's arrhythmogenic potential. Models assist to quantitatively relate…
Certara2010年8月21日
