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Publication

Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning

The objective of this study was to investigate the effects of carprofen administered immediately before…

Danielle Pillsbury2016年2月1日

Publication

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Danielle Pillsbury2016年2月1日

Publication

Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

In vitro-in vivo extrapolation of clearance, embedded in a clinical trial simulation, was used to…

Danielle Pillsbury2016年2月1日

Publication

Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy

Danielle Pillsbury2016年1月5日

Publication

Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield

Previous research has shown that postpartum administration of the nonsteroidal antiinflammatory drug (NSAID) sodium salicylate…

Danielle Pillsbury2016年1月1日

Publication

Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis

Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…

Danielle Pillsbury2016年1月1日

Publication

A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

Danielle Pillsbury2016年1月1日

Blog

Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko

Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…

Certara2015年12月1日

Blog

Modeling the Influence of Ethnicity on Drug Disposition

Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…

Certara2015年11月23日

Knowledge Base

9 Frequently Misunderstood Concepts in PK/PD Modeling

In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…

Nathan Teuscher2015年11月3日

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