Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko
Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…
Certara2015年12月1日
Modeling the Influence of Ethnicity on Drug Disposition
Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…
Certara2015年11月23日
9 Frequently Misunderstood Concepts in PK/PD Modeling
In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…
Certara2015年11月3日
Population PK & Dosing Implications for Cobimetinib in Cancer Patients
A population pharmacokinetic model was developed for cobimetinib in cancer patients. Covariates had minimal impact…
Certara2015年11月1日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model
Bioavailability of orally administered drugs can be influenced by a number of factors including release…
Certara2015年11月1日
Introducing OpenCDISC Enterprise 3.0
Pinnacle 21 is proud to announce the launch of OpenCDISC Enterprise 3.0, which will be…
Certara2015年10月27日
Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-release Tablets to Elderly and Young Subjects
Tramadol is frequently used in geriatric patients; however, pharmacokinetic (PK) publications on tramadol and O-desmethyltramadol…
Certara2015年10月27日
Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs
Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in…
Certara2015年10月1日
How to Optimize Your Drug Label Using Modeling and Simulation Technology
As a trained pharmacist and scientist, I think a lot about patient care and how…
Certara2015年9月29日
