9 Things Your Boss Wishes You Knew About PK/PD Modeling
Over the course of my career, I have taught the theory and practical applications of PK/PD…
Certara2015年9月15日
Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients
The published OS model and resultant simulations can be leveraged to support Phase II design…
Certara2015年9月1日
Are Physiologically-based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site
Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (Cmax) following intravenous administration. A proposed explanation is that invariably…
Certara2015年9月1日
Derivation for Logarithmic Trapezoidal AUC Calculation
Calculating area under the curve requires the use of two separate equations: one is follows…
Certara2015年8月5日
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
Certara2015年7月28日
Population Pharmacokinetic Modeling of Motesanib and Its Active Metabolite, M4, in Cancer Patients
Motesanib is a small molecule and potent multikinase inhibitor with antiangiogenic and antitumor activity. Population…
Certara2015年7月23日
How to Revamp Your Approach to Conventional IVIVC Models
An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…
Certara2015年7月21日
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance Using a QconCAT Technique
Transporter proteins expressed in the gastrointestinal tract play a major role in the oral absorption of some…
Certara2015年6月10日
Prediction of Voriconazole Non-linear Pharmacokinetics Using a Pediatric Physiologically-based Pharmacokinetic Modeling Approach
We read with interest the report by Zane and Thakker entitled ‘‘A PBPK model for…
Certara2015年5月1日
