Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
Nathan Teuscher2011年2月10日
What are Direct and Indirect Pharmacodynamic Models?
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…
Nathan Teuscher2011年2月8日
What is Modeling and Simulation?
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…
Nathan Teuscher2011年2月1日
Physiologically-based Pharmacokinetic Model for Topotecan in Mice
Topotecan is a chemotherapeutic agent of choice for the second-line treatment of recurrent ovarian cancer.…
Danielle Pillsbury2011年2月1日
Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by Use of a Stable Isotope in Patients with Epilepsy
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been…
Danielle Pillsbury2011年2月1日
Poor Correlation between Urinary Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by a Stable Isotope Method in Epilepsy Patients
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been…
Danielle Pillsbury2011年2月1日
Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science
The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of age in drug development and…
Danielle Pillsbury2011年2月1日
Unexpected Effect of Rifampin on the Pharmacokinetics of Linezolid: In Silico and In Vitro Approaches to Explain Its Mechanism
The effect of rifampin on the steady-state pharmacokinetics of linezolid was evaluated in an open-label,…
Danielle Pillsbury2011年2月1日
Critique of the Two-fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-drug Interactions
Current assessment of drug-drug interaction (DDI) prediction success is based on whether predictions fall within a two-fold range of the observed data. This strategy…
Danielle Pillsbury2011年2月1日
Applications of Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review
Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can help predict the…
Danielle Pillsbury2011年2月1日
