Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation
The aim of this study was to develop a pain relief model for a cyclooxygenase…
webdev2006年4月1日
Changes in Liver Volume from Birth to Adulthood: A Meta-analysis
A diversity of equations is available for the estimation of liver volume (LV), derived from…
webdev2005年12月1日
Kinetic Values for Mechanism-based Enzyme Inhibition: Assessing the Bias Introduced by the Conventional Experimental Protocol
The in vitro characterisation of a mechanism-based enzyme inactivator (MBEI) includes determination of the maximum…
webdev2005年11月1日
Model-based Development of Gemcabene, a New Lipid-altering Agent
The purpose of this study was to evaluate the value of model-based, quantitative decision making…
webdev2005年10月7日
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model
Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…
webdev2005年9月1日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation
A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…
webdev2005年9月1日
Modelling Approaches to Dose Estimation in Children
Most of the drugs on the market are originally developed for adults and dosage selection…
webdev2005年6月1日
Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity
It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…
webdev2005年4月1日
Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials
Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…
webdev2005年1月1日
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients
Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…
webdev2005年1月1日
