Modeling the Influence of Ethnicity on Drug Disposition
Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…
Certara2015年11月23日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model
Bioavailability of orally administered drugs can be influenced by a number of factors including release…
webdev2015年11月1日
How to Optimize Your Drug Label Using Modeling and Simulation Technology
As a trained pharmacist and scientist, I think a lot about patient care and how…
Certara2015年9月29日
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
Certara2015年7月28日
How to Revamp Your Approach to Conventional IVIVC Models
An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…
Certara2015年7月21日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux
A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin…
webdev2013年9月1日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part II—Prediction of P-glycoprotein Mediated Drug-drug Interactions with Digoxin
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo.…
webdev2013年9月1日
Application of In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-based Pharmacokinetic Modeling to Investigate the Impact of the CYP2C8 Polymorphism on Rosiglitazone Exposure
The purpose of this study was to predict the impact of the CYP2C8*3 genotype on…
webdev2013年6月1日
Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Mice
Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved as an immunosuppressant and for…
webdev2013年5月1日
A Physiologically-based Pharmacokinetic Modeling Approach to Predict Disease-drug Interactions: Suppression of CYP3A by IL-6
Elevated cytokine levels are known to downregulate expression and suppress activity of cytochrome P450 enzymes…
webdev2013年4月10日
