How to Perform IVIVC for Delayed Release Drug Formulations

In vitro-in vivo correlation (IVIVC) is a predictive mathematical tool that describes the relationship between an in vitro property of a drug dosage form and an in vivo pharmacokinetic response. Drug developers frequently use this approach to waive the requirement to show in vivo bioavailability or bioequivalence.
In theory, developing an IVIVC is straightforward for immediate release oral formulations. Delayed release drug formulations deliver a drug with a delay after its administration. IVIVC then becomes a real challenge. This webinar showed how to use a time correction factor to establish a meaningful IVIVC for delayed release formulation drugs.



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