2013年3月

Blog Knowledge Base

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

When I first began learning about pharmacokinetics, I was often confused by the mean residence…

Certara2013年3月28日

Publication

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…

Danielle Pillsbury2013年3月28日

Blog Knowledge Base

What is a Loading Dose?

Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…

Certara2013年3月22日

Knowledge Base

The Superposition Principle

Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…

Nathan Teuscher2013年3月14日

Publication

A Poor Metabolizer of Both CYP2C19 and CYP2D6 Identified by Mechanistic Pharmacokinetic Simulation in a Fatal Drug Poisoning Case Involving Venlafaxine

We present a fatal drug poisoning case involving venlafaxine (VEN). The deceased took his medication…

Danielle Pillsbury2013年3月10日

Publication

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…

Danielle Pillsbury2013年3月1日

Publication

Race and Drug Formulation Influence on Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients

Limited mycophenolic acid (MPA) data are available comparing racial influence on mycophenolate mofetil (MMF) and…

Danielle Pillsbury2013年3月1日

Publication

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

This article reports an analysis that aims to quantify the effect of fingolimod, an oral…

Danielle Pillsbury2013年3月1日

Publication

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Although smallpox has been eradicated, the United States government considers it a "material threat" and…

Danielle Pillsbury2013年3月1日

Publication

Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach

The development of in vitro-in vivo extrapolation (IVIVE), a 'bottom-up' approach, to predict pharmacokinetic parameters…

Danielle Pillsbury2013年3月1日

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2013年3月

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

What is a Loading Dose?

The Superposition Principle

A Poor Metabolizer of Both CYP2C19 and CYP2D6 Identified by Mechanistic Pharmacokinetic Simulation in a Fatal Drug Poisoning Case Involving Venlafaxine

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Race and Drug Formulation Influence on Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach

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