Why Should You Evaluate Dose Proportionality?
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…
Certara2011年2月17日
What is the Difference Between PK and TK?
Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development,…
Nathan Teuscher2011年2月15日
Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
Nathan Teuscher2011年2月10日
What are Direct and Indirect Pharmacodynamic Models?
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…
Nathan Teuscher2011年2月8日
What is Modeling and Simulation?
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…
Nathan Teuscher2011年2月1日
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides
Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…
Danielle Pillsbury2011年2月1日
Relationship Between AUC and Volume of Distribution
A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…
Nathan Teuscher2011年1月26日
Where Did the 80-125% Bioequivalence Criteria Come From?
Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…
Certara2011年1月24日
Generics and Bioequivalence
As the debate about health care in the United States continues forward, the term “generic…
Nathan Teuscher2011年1月10日
What are Compartmental Models?
Learn about compartmental models and their importance in pharmacokinetics. Find out how they simplify drug…
Nathan Teuscher2011年1月5日
