What is the Difference Between Individual and Population PK? 技術情報 What is the Difference Between Individual and Population PK? Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…Certara2011年3月14日
Blood or Plasma? Which Should You Assay for Drug Concentration? 技術情報 Blood or Plasma? Which Should You Assay for Drug Concentration? Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate…Certara2011年2月19日
Why Should You Evaluate Dose Proportionality? BlogKnowledge Base Why Should You Evaluate Dose Proportionality? Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…Certara2011年2月17日
What is the Difference Between PK and TK? 技術情報 What is the Difference Between PK and TK? Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development,…Certara2011年2月15日
Why are PK Parameters Lognormally Distributed? 技術情報 Why are PK Parameters Lognormally Distributed? The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…Certara2011年2月10日
What are Direct and Indirect Pharmacodynamic Models? 技術情報 What are Direct and Indirect Pharmacodynamic Models? When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…Certara2011年2月8日
What is Modeling and Simulation? 技術情報 What is Modeling and Simulation? I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…Certara2011年2月1日
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Publication Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…Certara2011年2月1日
Relationship Between AUC and Volume of Distribution Knowledge Base Relationship Between AUC and Volume of Distribution A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…Certara2011年1月26日
Where Did the 80-125% Bioequivalence Criteria Come From? BlogKnowledge Base Where Did the 80-125% Bioequivalence Criteria Come From? Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…Certara2011年1月24日