What Does Clearance Mean?
Drug clearance is an extremely important topic in the science of pharmacokinetics. Drug clearance defines…
Nathan Teuscher2010年6月13日
Understanding Volume of Distribution
One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all…
Certara2010年6月5日
Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis
Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium…
Danielle Pillsbury2010年6月1日
What is Pharmacodynamics?
Starting with definitions is always helpful… so after defining pharmacokinetics, a definition for pharmacodynamics is…
Nathan Teuscher2010年5月24日
What is Pharmacokinetics?
You might think this is a simple question, especially for an expert in pharmacokinetics. Well,…
Nathan Teuscher2010年5月16日
Population Pharmacokinetic/Pharmacodynamic Model for a C.E.R.A. in Both ESA-naive and ESA-treated Chronic Kidney Disease Patients with Renal Anemia
This study aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model for C.E.R.A., a continuous erythropoietin…
Danielle Pillsbury2010年5月1日
Population Pharmacokinetics of Teduglutide Following Repeated Subcutaneous Administrations in Healthy Participants and in Patients with Short Bowel Syndrome and Crohn’s Disease
Teduglutide is a GLP-2 analog currently evaluated for the treatment of short bowel syndrome, Crohn's…
Danielle Pillsbury2010年1月1日
Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome
Teduglutide, a synthetic glucagon-like peptide-2 (GLP-2) analog with activity relating to the regeneration, maintenance, and…
Danielle Pillsbury2009年12月1日
Is a Thorough QTc Study Necessary? The Role of Modeling and Simulation in Evaluating the QTc Prolongation Potential of Drugs
Concentration-QT (C-QT) modeling has been conducted for multiple compounds at various stages of development in…
Danielle Pillsbury2009年11月1日
Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics
We developed a drug-disease simulation model to predict antitumor response and overall survival in phase…
Danielle Pillsbury2009年9月1日
