pre-update Archives

Publication

Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations

Prediction accuracy of pharmacokinetic parameters is often assessed using prediction fold error, i.e., being within 2-, 3-, or…

Danielle Pillsbury2014年9月1日

Publication

Development of Physiologically-based Pharmacokinetic Model to Evaluate the Relative Systemic Exposure to Quetiapine After Administration of IR and XR Formulations to Adults, Children, and Adolescents

Quetiapine is an atypical antipsychotic drug with a high permeability, moderate solubility and defined as…

Danielle Pillsbury2014年9月1日

Publication

Understanding the Effect of the HCV Polymerase Inhibitor Mericitabine on Early Viral Kinetics in the Phase 2 JUMP-C and PROPEL Studies

Danielle Pillsbury2014年8月21日

Knowledge Base

Adding a Placebo Component to Your PK/PD Model in Phoenix

PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…

Nathan Teuscher2014年8月20日

Publication

Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice

Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…

Danielle Pillsbury2014年8月15日

Knowledge Base

Bioanalytical Calibration Curves

At the request of a reader, I have decided to extend my series on bioanalysis…

Nathan Teuscher2014年8月12日

Publication

Comparative Benefit of Malaria Chemoprophylaxis Modeled in United Kingdom Travelers

Danielle Pillsbury2014年8月5日

Publication

Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival

Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…

Danielle Pillsbury2014年8月1日

Publication

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling…

Danielle Pillsbury2014年8月1日

Knowledge Base

Radiometric Analysis

One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…

Nathan Teuscher2014年7月29日

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pre-update

Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations

Development of Physiologically-based Pharmacokinetic Model to Evaluate the Relative Systemic Exposure to Quetiapine After Administration of IR and XR Formulations to Adults, Children, and Adolescents

Understanding the Effect of the HCV Polymerase Inhibitor Mericitabine on Early Viral Kinetics in the Phase 2 JUMP-C and PROPEL Studies

Adding a Placebo Component to Your PK/PD Model in Phoenix

Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice

Bioanalytical Calibration Curves

Comparative Benefit of Malaria Chemoprophylaxis Modeled in United Kingdom Travelers

Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

Radiometric Analysis

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