Certara’s Immuno-oncology (IO) Simulator is a cutting-edge quantitative systems pharmacology (QSP) modeling platform designed to predict optimal drug combinations, dosing regimens, and biomarkers in virtual patients with solid tumors. When monotherapies do not effectively address the complexities of solid tumors, a new approach is needed where combination therapies can be considered. By simulating the complex dynamics of the Cancer Immunity Cycle, the IO Simulator empowers researchers to make data-driven decisions for immuno-oncology therapies. This innovative tool integrates pre-clinical data to refine models and forecast clinical outcomes, enabling the development of personalized treatment strategies for specific indications and tumor phenotypes.