Certara’s Immuno-oncology (IO) Simulator is a cutting-edge QSP modeling platform designed to predict optimal drug combinations, dosing regimens, and biomarkers in virtual patients. By simulating the complex dynamics of the Cancer Immunity Cycle, the IO Simulator empowers researchers to make data-driven decisions for immuno-oncology therapies. This innovative tool integrates pre-clinical data to refine models and forecast clinical outcomes, enabling the development of personalized treatment strategies for specific indications and tumor phenotypes.
Immuno-oncology Simulator™
Revolutionizing immuno-oncology with predictive modeling
Learn more about the Immuno-oncology Simulator
Features of the IO Simulator immuno-oncology modeling platform
The IO Simulator offers a mechanistic model of the Cancer Immunity Cycle, delivered through QSP Designer software. It facilitates modular development of a compound’s mechanism of action, calibrated with pre-clinical data, and integrates these models to predict clinical outcomes. Virtual trials conducted with the IO Simulator account for tumor heterogeneity, providing insights into optimal dosing and patient stratification biomarkers.
Modules of IO Simulator
- Tumor, lymph, and blood compartments
- Tumor cells
- T cells
- Dendritic cells
- Macrophages
- NK cells
- Multiple cytokines
Drug modalities
- mAb
- bsAb
- ADC
- 低分子
QSPの専門家紹介
関連情報
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Certara offers Quantitative Systems Pharmacology (QSP) platform models across diverse therapeutic areas, enabling data-driven insights to accelerate drug development. 当社のカスタマイズされたソリューションは、複雑な生物学的システムを統合し、研究および臨床現場における科学的な意思決定をサポートします。
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Ask us how the IO Simulator can build confidence into your immuno-oncology therapies.