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In 2022, Simcyp continued its leadership in advancing the use of physiologically based pharmacokinetics (PBPK) and quantitative systems pharmacology (QSP) for innovative drug development and regulatory science. We share some highlights here:

New Drug Approvals

The industry-leading Simcyp whole body PBPK Simulator platform is used for virtual decision-making in drug development, from early development through clinical, regulatory approval and post-marketing phases. The Simcyp Simulator predicts how the drug will move through the body and how a drug is affected by other medications, ethnicity, age, genetics and disease-state.

Simcyp is a proven approach for reducing, informing and/or eliminating clinical trials. The Simcyp Simulator has been used to predict drug performance on untested patient populations, advise on dosing decisions, and inform drug labels for >100 novel drugs. This translates into hundreds of label claims approved by global regulators using Simcyp in lieu of costly clinical studies.

See the list of the 100 drugs that used Simcyp in lieu of clinical studies
New Drug Approvals
Driving Advances in Technology

Driving Advances in Technology

We are experiencing a rapid expansion in drug development, fueled by our increased understanding of systems biology and underlying pathology; the proliferation of reliable data sources, such as genomics, proteomics and high throughput screening; and an explosion in computing capabilities. Simcyp harnesses these technology advances and combines them with regulatory guidance to innovate our PBPK, QSP and QSTS software platforms and apply new learnings via tech-enabled consulting. This year, new product launches include:

Simcyp Discovery – Watch the Demo, Take a Test Run

Winner of 2022 Edison Award for
COVID-19 Vaccine Model

エジソン賞の受賞は、ゲームチェンジャーとなる新製品開発やサービスの立ち上げに成功した企業にとって、最高の栄誉の一つです。

Certara’s COVID-19 Vaccine Model uses QSP to facilitate global vaccine decision-making, helping to answer questions such as what are the optimal dose and timing, are there differences in immune response with age and ethnicity, and what is the expected duration of antibody response.

Read more on Certara’s Mind-blowing QSP Work
Winner of 2022 Edison Award forCOVID-19 Vaccine Model

Second Year in a Row for Simcyp:
R&D 100 Award

Secondary Intelligence software has won an R&D 100 Award, which recognizes the top 100 “R&D pioneers and their revolutionary ideas in science and technology” each year. Secondary Intelligence software is the first and only application that quantitatively predicts the risk of adverse effects and safety issues derived from secondary pharmacology that may impede the clinical development of a drug.

Learn more about QSTS and Secondary Intelligence

Educational Leadership

Since its inception in 2000, the Simcyp team has committed itself to teaching and education to advance our field. 2022 was another prolific year for the team, with workshops, on-line training, podium speeches, poster presentations, peer reviewed publications, and webinars.

Further, during the past 2 years, Simcyp was invited to speak by global regulators (FDA, EMA, PMDA) at more than 10 workshops/events focused on advances in PBPK and QSP.

See the full list of 2022 Simcyp publications
Educational Leadership

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