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PAGE 2025

Conference: 33rd PAGE Meeting

開催日: June 4-6, 2025

エリア： Thessaloniki, Greece

Booth: 11 & 12

Connect with Certara’s leading scientists and pharmacometric experts

Join us at this year’s event, where a dynamic and highly experienced team from Certara will be on site. Visit our booth to exchange ideas, discuss your latest work, and explore how we can collaborate to advance drug development.

You’ll have the opportunity to meet with renowned experts including Piet van der Graaf, PharmD, PhD; Rik de Greef, MSc; Mirjam Trame, PharmD, PhD; Masoud Jamei, PhD; Mark Sale, MD; Keith Nieforth, PharmD; and more than 40 other scientists will be on site.

2025 Annual European Futbol Pharmacometrics Collective

Certara is proud to return with this annual tradition. Players of any skill level are encouraged to participate, and spectators are also welcome for the evening fun.

Read the full details and register here

Meet with us at PAGE 2025!

Connect 1:1 with our experts in mechanistic modeling, quantitative and statistical modeling, and strategic drug development—from lead optimization and early development (toxicology, CMC) to clinical pharmacology, regulatory strategy, and advanced data analysis through pharmacometrics.

Complete the form to schedule a personalized meeting.

Where to hear Certara insights and expertise

2025年6月3日 (火曜日)
参加登録はこちら
Pre-Conference Workshop: A Hands-On Workshop with Simcyp Designer for Tailored PBPK-PD/QSP Models

Tutors: Abdallah Derbalah, Sr. Research Scientist and Felix Stader, Associate Principal Scientist

エリア： 2025年6月3日 | IN PERSON, Thessaloniki Concert Hall (room CR-2) Thessaloniki, Greece

Would you like to modify and tailor population PBPK models? This course will review the principles of PBPK modelling, using the Simcyp Simulator and how to use Simcyp Designer to modify existing PBPK models with your own extension and link them to custom-built PD/QSP models. We will have lectures to introduce the PBPK models to be changed and have hands-on exercises to train the customization of PBPK models with the Designer. No prior knowledge is required. Access to the Simcyp Simulator and Simcyp Designer will be provided. Participant are required to bring their own laptops as the workshop is hands-on intensive.

Read the full details and register here

Showcasing scientific innovation

We’re excited to present over 30 accepted posters from our talented team of pharmacometricians, highlighting their latest research and innovative approaches. Our scientists are dedicated to advancing what’s possible in drug development by applying cutting-edge modeling techniques and methodologies.

Drug/Disease Modeling: Paediatrics
A semi-mechanistic approach to model simultaneously the ADC, total mAb and cytotoxic payload of sacituzumab tirumotecan

Presenting Author: Thijs Zweers

Population pharmacokinetic (PPK) modeling analyses of tovorafenib in patients with RAF-altered, relapsed/refractory (r/r) pediatric low-grade glioma (pLGG), advanced solid tumors, and healthy adults

Presenting Author: Katrina Hui

Application of Quantitative Systems Pharmacology (QSP) Approach to Guide Development of a Bispecific CD40-EpCAM Antibody, KK2269

Presenting Author: Birses Debir

Development of a framework for mechanistic modelling and interspecies scaling for AAV gene therapy

Presenting Author: Harshbir Sandhu

A minimal physiologically-based pharmacokinetic/pharmacodynamic mouse xenograft model to inform the evaluation of 212Pb-based Radio-DARPins targeting DLL3

Presenting Author: Mirjam Trame

Operating Characteristics of M-protein Dynamic Metrics to Support Early Decisions in Multiple Myeloma

Presenting Author: Mathilde Marchand

Drug/Disease Modeling: 悪性腫瘍
Validating the D-RSC disease progression modelling framework for Duchenne muscular dystrophy and evaluating the long-term impact of givinostat therapy in pediatric patients

Presenting Author: Anna Largajolli

Changes in the relative contribution of hepatic metabolism and glomerular filtration to total plasma clearance in children younger than four years of age; when is scaling for the dominant elimination route in adults appropriate?

Presenting Author: Elke Krekels

Investigating survivorship bias in disease progression modelling for Duchenne muscular dystrophy

Presenting Author: Stephen Duffull

Towards Developing a Harmonizing Framework for PK and/or PKPD Scaling for Pain Medications in the Pediatric Population

Presenting Author: Soumya Perinparajah

Cabotegravir Population Pharmacokinetic Analysis of Adult and Adolescents pooled population who are living with HIV or at risk for HIV and receiving HIV pre-exposure prophylaxis (PrEP)

Presenting Author: Amy Chung
In collaboration with GSK, ViiV, HPTN and IMPAACT networks (HIV networks)

Drug/Disease Modelling: Other Topics
Development of a framework for mechanistic modelling and interspecies scaling for AAV gene therapy

Presenting Author: Manon Wigbers

Mechanistic Modelling of CAR T-cell Therapy for Multiple Myeloma to assess multi-antigen targeting and identify factors associated with response.

Presenting Author: Vicky Kostiou

Applications of an Immunogenicity QSP Platform: Predictive Modelling for ADA and PK Impact for Biotherapeutic Combination

Presenting Author: Rachel Rose

A new model of Tumor Growth Inhibition for pseudo-progression in Immuno-Oncology

Presenting Author: Giovanni Di Veroli

Investigating the Role of Epithelial Barrier Function in Inflammatory Bowel Disease with Mechanistic Modeling

Presenting Author: Julia Stolk

Methodology: New modelling approaches
Aggregate data modeling in R: a new method for fitting pharmacometrics models to summary-level data

Presenting Author: Hidde van de Beek

Multi-objective Optimization for Population Pharmacokinetic (PopPK) Model Selection Using NSGA-II and pyDarwin

Author: James Craig

Announcement of Machine Learning Benchmarking

Presenting Author: Mark Sale (Liang Zhao2. 1Certara, 2UCSF)

Simulation With Parameter Uncertainty Using Nmsim

Presenting Author: Boris Grinshpun

Methodology: New Tools
ADPO: Automatic-differentiation-assisted parametric optimization algorithm

Presenting Author: Mark Sale

Multi-Objective Optimization for Population Pharmacokinetic Model Selection: Evaluating NSGA-III Performance.

Author: James Craig

Multi-objective Optimization for Population Pharmacokinetic Model Selection in pyDarwin

Author: James Craig

Software Demonstration
Pirana–Simcyp Virtual Bioequivalence (VBE) Workflow: Software Demonstration and Case Study on Paliperidone Palmitate Long-Acting Injectables

Presenting Author: James Craig

Turbocharging Computation Efficiency: A Tutorial on Hierarchical Parallel Computing in R

Presenting Author: Mahmoud Ali

Drug/Disease Modelling – Absorption and PBPK
Leveraging PBPK Modelling to Optimize Oligonucleotide Therapeutics: Sustained-Release Strategies for Enhanced Targeting Specificity

Author: Felix Stader

A best practice framework for applying physiologically based pharmacokinetic modelling to predict pH-dependent Drug-Drug Interactions

Presenting Author: Chara Litou

Drug/Disease Modelling - CNS
Joint Exposure-Response Analysis of PET Amyloid Plaque Data from the BACE1 Inhibitor Verubecestat and Amyloid mAbs Trials Enhances the Understanding of Drug Effects

Presenting Author: Eline van Maanen

Clinical Applications
Physiologically based pharmacokinetic modelling to predict antibody exposure in patients with hepatic impairment

Presenting Author: Felix Stader

Methodology - Estimation Methods
ADPO: Automatic-differentiation-assisted parametric optimization algorithm (benchmark).

Presenting Author: Mark Sale

Methodology - Study Design
Towards the Best Practices to Create Virtual Healthy Control Populations for Organ Impairment Studies

Presenting Author: Roeland E. Wasmann

Methodology - Model Evaluation
Exploring tidyvpc, an efficient and versatile toolkit for performing visual predictive checks (VPCs) in pharmacometrics models.

Presenting Author: Suchaya Sanhajariya

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