Month: 2014年11月
A Mechanistic Framework for the In Silico Prediction of Regional Passive Gut Wall Permeability and Its Inter-individual Variability in Humans
Physiologically-based IVIVC at a Population Level—Deconvoluting In Vivo Dissolution and Identifying Sources of Variability
Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms
Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase. The purpose of these analyses was to develop a population pharmacokinetics model to characterize the vigabatrin concentration–time profile for adults and children with refractory complex partial seizures (rCPS) and for children with infantile spasms (IS); to identify covariates that affect its disposition, and to enable predictions of … Continued
