Versatile tool for translational modeling and simulation

It is now well-accepted that physiologically-based pharmacokinetic (PBPK) modeling and simulation is a powerful tool in drug development. PBPK helps answer a myriad of “what if” questions that cannot be addressed without lengthy and expensive clinical studies.

PBPK also has numerous applications to inform critical decisions early in the R&D process. The new Simcyp Discovery Simulator is an intuitive PBPK software that delivers confidence in decision-making during the pre-Investigational New Drug (IND) Application and translational stages. Derived from the gold-standard Simcyp Simulator, Simcyp Discovery advances and accelerates small molecule discovery and development.

Triage the best drug candidates

High-throughput screening speeds up the process of identifying promising lead compounds. Simcyp Discovery facilitates rapid batch screening of thousands of potential compounds to identify the most promising candidates.

It also helps guide decisions regarding the optimal laboratory objectives for a chemical series to achieve the target product profile (TPP).

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Triage the best drug candidates

Defining lab objectives to achieve TPP

Early PK, PD and FIH dose predictions
DDI risk assessment
Early formulation screening

Prediction of exposure in tox studies

TPP = target profile; PK = pharmacokinetics; PD = pharmacodynamics; FIH = first-in-human; DDI = drug-drug interactions

Predict first-in-human (FIH) PK

Predict first-in-human (FIH) PK

A first-in-human protocol is required in an IND application. In vitro in vivo extrapolation (IVIVE) – linked PBPK can be applied for PK and dose prediction in early stages where data are limited, and it enables a mechanistic understanding of the effect of physiological variables.

Simcyp Discovery uses PBPK to predict early drug development outcomes by delivering a unified interface for both animal and human simulation for translational research. It includes PBPK models for human, mouse, rat, dog and monkey. Establishing IVIVE in pre-clinical species can inform IVIVE and PBPK model building in human. Simcyp Discovery provides a range of model options – the minimal PBPK model, the full PBPK model, a compartmental model, which includes 1, 2 and 3 compartmental PK models, as well as a first order (FO) model and advanced dissolution, absorption and metabolism (ADAM) model.

To determine the required dose to achieve the desired concentration, you can conduct simulations at different dose levels and frequencies. You can also perform different sensitivity analyses using the automated sensitivity analysis tool.

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Flag victim and perpetrator DDI liability

Assessment of drug-drug interaction (DDI) liabilities is a critical safety component of your drug development program. Early predictions of harmful DDIs inform rapid decision-making.

Simcyp Discovery’s static DDI calculator flags DDI risk for enzymes and transporters based on published regulatory guidance from the FDA, EMA and PMDA. You can explore DDI risk from both perpetrator and victim perspectives.

Simcyp Discovery also supports the prediction of exposure in toxicology studies and identifies drug profile risks such as non-linear or time-dependent PK.

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Flag victim and perpetrator DDI liability
Conduct early formulation screening

Conduct early formulation screening

PBPK is increasingly being applied to formulation development by helping to guide the development of new and alternate formulations, thereby increasing the number and type of patients that can benefit from therapies.

Simcyp Discovery offers capabilities to strengthen work in early formulation screening. You can perform sensitivity analysis to determine what is needed to improve the formulation, such as increasing solubility using a spray-dried dispersion formulation or reducing particle size via micronisation.

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Hannah Jones
Hannah Jones, PhD Senior Vice President, Head of PBPK Consulting Services

グローバル製薬企業において 20 年以上にわたって研究開発に携わっていました。特に、PBPK や PK/PD モデリングの分野で優れた実績を残しています。PBPK や PK/PD モデリング、DMPK に関連した 50 件以上の論文を発表しています。モデリング&シミュレーション手法の活用を通して医薬品研究開発プログラムに多くの貢献を果たしてきました。

Bio Pic MasoudJamei
Masoud Jamei, PhD Senior Vice President, Simcyp Research & Development

Simcyp の設計や開発、実装を担当する科学者とプログラマーチームを統括しています。in vitro-in vivo 外挿や PBPK/PD モデル、トップダウンアプローチである PopPK モデル解析手法の PBPK モデルへの応用など様々な分野に精通しています。

Bio Pic IanGardner
Iain Gardner, PhD Sr. Scientific Advisor and Head of Translational Science.

Iain leads the science team that is responsible for further developments of the population based physiologically-based PK/PD simulators to meet the needs of Simcyp Consortium members. Prior to joining Certara, he spent 12 years working in the Pharmacokinetics, Dynamics and Metabolism Department at Pfizer Global Research & Development.

How can we increase confidence in your pre-IND decisions?

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