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Hallmarks of neurodegenerative disease: A systems pharmacology perspective

Authors: Peter Bloomingdale, Tatiana Karelina, Vidya Ramakrishnan, Suruchi Bakshi, Florence Véronneau-Veilleux, Matthew Moye, Kazutaka Sekiguchi, Guy Meno-Tetang, Aparna Mohan, R. Maithreye, Veena A. Thomas, Frank Gibbons, Antonio Cabal, Jean-Marie Bouteiller, Hugo Geerts

Age-related central neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are a rising public health concern and have been plagued by repeated drug development failures. The complex nature and poor mechanistic understanding of the etiology of neurodegenerative diseases has …

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