Limitations of MIC as Sole Metric of Pharmacodynamic Response Across the Range of Antimicrobial Susceptibilities within a Single Bacterial Species

The minimum inhibitory concentration (MIC) of an antimicrobial drug for a bacterial pathogen is used as a measure of the bacterial susceptibility to the drug. However, relationships between the antimicrobial concentration, bacterial susceptibility, and the pharmacodynamic (PD) inhibitory effect on the bacterial population are more complex. The relationships can be captured by multi-parameter models such … Continued

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